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Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases
Author(s) -
FUJIWARA ATSUSHI,
KOBAYASHI HIROYASU,
MASUYA MASAHIRO,
MARUYAMA MITSUKO,
NAKAMURA SHIHO,
IBATA HIDENORI,
FUJIMOTO HAJIME,
OHNISHI MASAHIRO,
URAWA MASAHITO,
NAITO MASAHIRO,
TAKAGI TAKEHIRO,
KOBAYASHI TETSU,
GABAZZA ESTEBAN C.,
TAKEI YOSHIYUKI,
TAGUCHI OSAMU
Publication year - 2012
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2012.02167.x
Subject(s) - fibrocyte , medicine , interstitial lung disease , idiopathic pulmonary fibrosis , pulmonary fibrosis , pathology , pulmonary function testing , lung , fibrosis , hypersensitivity pneumonitis , population , usual interstitial pneumonia , pathogenesis , immunology , environmental health
Background and objective: Interstitial lung diseases (ILD) are characterized by progressive interstitial pulmonary fibrosis and a decline in lung function. Fibrocytes are bone marrow‐derived mesenchymal progenitor cells that may play a role in the pathogenesis of pulmonary fibrosis. Circulating fibrocyte numbers have been correlated with the prognosis of patients with idiopathic pulmonary fibrosis. The aim of the present study was to evaluate the relationship between circulating fibrocytes, and parameters of disease activity and progression in several groups of patients with ILD. Methods: The study population comprised 41 patients with ILD and seven healthy control subjects. Circulating CD45 + collagen‐I + fibrocytes were evaluated by flow cytometry. Results: The number of circulating fibrocytes was significantly increased in all patients with ILD and particularly in patients with idiopathic interstitial pneumonitis and interstitial pneumonitis associated with collagen vascular disease as compared with healthy control subjects. The numbers of circulating fibrocytes were significantly correlated with pulmonary function test parameters and with serum levels of sialylated carbohydrate antigen, a marker of disease activity. Temporal changes in circulating fibrocyte numbers were evaluated in two patients, and the results suggested that these changes correlated with the activity of ILD. Conclusions: The results from this study provide further evidence for the role of circulating fibrocytes in fibrotic lung diseases.