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Iodine‐123 metaiodobenzylguanidine scintigraphic assessment of pulmonary vascular status in patients with chronic obstructive pulmonary disease
Author(s) -
KOIZUMI Tomonobu,
URUSHIHATA Kazuhisa,
HANAOKA Masayuki,
TSUSHIMA Kenji,
FUJIMOTO Keisaku,
FUJII Tadashige,
KUBO Keishi
Publication year - 2010
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2010.01853.x
Subject(s) - medicine , copd , scintigraphy , cardiology , lung , pulmonary function testing , pulmonary hypertension , pulmonary artery , pulmonary disease , lung volumes , nuclear medicine , radiology
Background and objective: Lung uptake of iodine‐123 metaiodobenzylguanidine ( 123 I‐MIBG) is used as an indicator of pulmonary endothelial function. Decreased lung uptake of 123 I‐MIBG has been demonstrated in patients with COPD as compared with normal subjects. The present study was performed to examine the relationship between lung uptake of 123 I‐MIBG and pulmonary artery pressure (Ppa) at rest and during exercise, in patients with COPD. Methods: 123 I‐MIBG scintigraphy was performed in 19 patients with COPD. Anterior planar images were acquired 15 min after the injection of 123 I‐MIBG, and the total lung to upper mediastinum ratio (LMR) was calculated for both lungs. Right heart catheters were used to monitor Ppa continuously at rest and during exercise. Exercise was performed on an electrically braked bicycle ergometer at a constant workload of 25 W for 3 min. Results: In COPD patients the LMR were not correlated with the pulmonary function parameters measured before exercise, including FEV 1 , PaO 2 , DL CO , or Ppa at rest. However, the percentage increase in Ppa during exercise was significantly correlated with LMR. Conclusions: Evaluation of the kinetics of lung uptake of 123 I‐MIBG may be a novel scintigraphic tool for the assessment of exercise‐induced pulmonary hypertension in patients with COPD.