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Elevated alveolar nitric oxide concentration after environmental challenge in hypersensitivity pneumonitis
Author(s) -
SHIRAI Toshihiro,
IKEDA Masaki,
MORITA Satoru,
ASADA Kazuhiro,
SUDA Takafumi,
CHIDA Kingo
Publication year - 2010
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2010.01726.x
Subject(s) - medicine , hypersensitivity pneumonitis , nitric oxide , exhaled nitric oxide , pneumonitis , lung , anesthesia , lung function , gastroenterology
We describe a 57‐year‐old male patient admitted to hospital with hypersensitivity pneumonitis (HP) that resolved without treatment. The total and alveolar nitric oxide (NO) concentrations were measured on initial admission and after re‐exposure to his home environment. Following environmental exposure he became ill again, alveolar NO concentration was increased to the same level as on initial admission and impaired pulmonary function and radiologic abnormalities were found. It suggested a diagnosis of environmentally induced HP. The clinical value of measuring alveolar NO as an acute‐phase reactant in HP is demonstrated in this patient.