Premium
Pulmonary alveolar proteinosis in a patient with Behcet's disease
Author(s) -
UCHIYAMA Michihiro,
NAGAO Tsuyoshi,
HATTORI Aritoshi,
FUJII Tatsuya,
ICHIWATA Toshio,
NAKATA Koh,
TANI Kenzaburo,
HAYASHI Takuya
Publication year - 2009
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2008.01450.x
Subject(s) - medicine , pulmonary alveolar proteinosis , behcet disease , antibody , disease , immunology , lung , immune system , pathology , dermatology
Secondary pulmonary alveolar proteinosis (PAP) has been described in several clinical settings that can be grouped into three main categories: infections of the lung; haematological malignancies and other conditions that alter the patient's immune status; and exposure to inhaled chemicals and minerals. Recent studies reported that anti‐granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) antibody was present in the serum of patients with idiopathic PAP but not in patients with secondary PAP or in normal subjects. The present report describes the interesting case of a patient with Behcet's disease and PAP. The absence of anti‐GM‐CSF antibodies in this patient suggested a diagnosis of secondary PAP.