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Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?
Author(s) -
HOUSHMAND Massoud,
BANOEI Mohammad Mehdi,
TABARSI Payam,
PANAHI Mehdi Shafa Shariat,
KASHANI Baharak Hooshiar,
EBRAHIMI Golnaz,
ZARGAR Laleh,
FARNIA Parissa,
MORRIS Matthew W.,
MANSOURI Davood,
VELAYATI Ali Akbar,
MIRSAEIDI Mehdi S.
Publication year - 2007
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2007.01163.x
Subject(s) - haplogroup , mitochondrial dna , tuberculosis , human mitochondrial dna haplogroup , medicine , mycobacterium tuberculosis , mitochondrion , reactive oxygen species , haplotype , genetics , immunology , genotype , biology , gene , pathology
Background and objectives: Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis , an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population. Methods: Mitochondrial DNA haplogroups M, N, J and K were studied by PCR‐restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons. Results: There were no statistically significant differences between those with TB and the control group. Conclusions: There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.