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NRAMP1 and TNF‐α polymorphisms and susceptibility to tuberculosis in Thais
Author(s) -
VEJBAESYA Sasijit,
CHIERAKUL Nitipatana,
LUANGTRAKOOL Panpimon,
SERMDUANGPRATEEP Chutima
Publication year - 2007
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2006.01037.x
Subject(s) - thais , tuberculosis , genotype , medicine , allele , tumor necrosis factor alpha , immunology , gene , untranslated region , genetics , biology , pathology , messenger rna , demography , sociology
Objective and background: Polymorphisms in the natural resistance‐associated macrophage protein gene 1 (NRAMP1) and tumour necrosis factor (TNF)‐α gene have been found to be associated with susceptibility to tuberculosis in different populations. However, the results are inconsistent. This study aimed to determine whether NRAMP1 and TNF‐α variants are associated with tuberculosis in Thais. Methods: Polymorphisms of NRAMP1 at INT4, D543N and the 3′ untranslated region, and of TNF‐α at +488, −238, and −308, were examined in 149 tuberculosis patients and 147 healthy controls. PCR using sequence‐specific oligonucleotides and sequence‐specific priming were used to genotype the NRAMP1 and TNF polymorphisms, respectively. Results: There were no significant differences in the distribution of the genotype frequencies for the NRAMP1 and TNF‐α polymorphisms between the patients and controls. Conclusions: The NRAMP1 and TNF‐α genes are not associated with susceptibility to tuberculosis in Thais.