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Duration of action of the salmeterol/fluticasone combination inhaler administered in the evening: A randomized controlled trial in childhood asthma
Author(s) -
ALDINGTON Sarah,
WILLIAMS Mathew,
WEATHERALL Mark,
BEASLEY Richard
Publication year - 2006
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2006.00888.x
Subject(s) - medicine , bronchodilator , asthma , salmeterol , fluticasone , evening , placebo , inhaler , inhalation , bronchodilation , anesthesia , confidence interval , physics , alternative medicine , pathology , astronomy
Objective and background: To investigate the duration of bronchodilator action of a salmeterol/fluticasone combination (SFC) inhaler when administered in the evening to children with asthma. Methodology: Design: A double‐blind, placebo‐controlled, cross‐over study. Setting: Hospital inpatient. Subjects: Fourteen children aged between 4 and 11 years with mild to moderate asthma (FEV 1 > 60% predicted) who exhibited a 15% increase in FEV 1 with bronchodilator. Interventions: Subjects inhaled, in random order, either SFC (100/50 µg) or placebo, via accuhaler, at 20.00 hours on two separate occasions with at least 3 days between study days. Outcome measures: Lung function measurements including FEV 1 , PEF, specific airways conductance (sGaw) and maximum expiratory flow at 25–75% of vital capacity were measured at baseline, 2, 12, 16, 20 and 24 h. Results: For all lung function parameters SFC resulted in significantly greater bronchodilation than placebo for at least 20 h after inhalation. At 24 h, the increase in FEV 1 and PEF compared with placebo was 0.08 L (95% confidence interval: −0.18 to 0.02, P = 0.16) and 27 L/min (95% confidence interval: −47 to −6, P = 0.004), respectively. Conclusions: The single administration of SFC via an accuhaler in the evening resulted in significant bronchodilation for at least 20 h in children with asthma.