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Elevated serum surfactant protein A and D in pulmonary alveolar microlithiasis
Author(s) -
TAKAHASHI Hiroki,
CHIBA Hirofumi,
SHIRATORI Masanori,
TACHIBANA Teruo,
ABE Shosaku
Publication year - 2006
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2006.00844.x
Subject(s) - pulmonary surfactant , surfactant protein d , medicine , surfactant protein a , pulmonary alveolus , surfactant protein c , pathology , pulmonary function testing , respiratory disease , lung , biochemistry , biology , receptor , innate immune system
Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by widespread localization of calcispherites in the alveolar spaces. The authors report two cases of PAM, with markedly elevated sera concentrations of surfactant protein‐A and surfactant protein‐D, which showed a tendency to increase as the disease progressed. Therefore, surfactant protein‐A and surfactant protein‐D may function as serum markers to monitor the disease activity and progression of PAM.