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Efficacy and safety of iodopovidone pleurodesis through tube thoracostomy
Author(s) -
AGARWAL Ritesh,
AGGARWAL Ashutosh N.,
GUPTA Dheeraj
Publication year - 2006
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2006.00792.x
Subject(s) - medicine , thoracostomy , pleurodesis , pneumothorax , surgery , effusion , empyema , chest tube , pleural effusion , malignant pleural effusion , anesthesia , saline , pleural cavity , visual analogue scale
Objective: To evaluate the efficacy and safety of iodopovidone as an agent for pleurodesis through tube thoracostomy in patients with recurrent pleural effusions and pneumothorax. Methods: This was a prospective study in which pleurodesis was performed with a solution of 20 mL 10% iodopovidone and 80 mL normal saline solution infused through a tube thoracostomy and left in the pleural cavity for 4 h. Results: A total of 64 patients (34 men) with a mean (±SD) age of 47.1 ± 15.4 years were included. There were 37 cases of pleural effusion and 27 of pneumothorax. A complete response (neither reaccumulation of fluid nor recurrence of pneumothorax) was obtained in 32 (86.5%) patients with pleural effusion and 25 (92.6%) patients with pneumothorax. A second procedure (i.e. repeated pleurodesis) was attempted successfully in four patients in the pleural effusion group. All patients experienced chest pain to a varying degree as recorded on a Visual Analogue Scale (median 50.5, range 10–95). Seven patients developed fever and one immunocompromised patient developed empyema following the procedure. There were no recurrences at a median follow up of 5 months (range 3–15 months) in the pleural effusion group, and 13 months (range 6–24 months) in the pneumothorax group. Conclusions: Iodopovidone can be used as an effective and safe agent for (chemical) pleurodesis (through tube thoracostomy), which is inexpensive and readily available.