Premium
Pulmonary alveolar proteinosis associated with psoriasis and complicated by mycobacterial infection: Successful treatment with granulocyte‐macrophage colony stimulating factor after a partial response to whole lung lavage
Author(s) -
ABDUL RAHMAN Jamalul Azizi,
MOODLEY Yuben P.,
PHILLIPS Martin J.
Publication year - 2004
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2004.00594.x
Subject(s) - pulmonary alveolar proteinosis , medicine , granulocyte macrophage colony stimulating factor , lung , granulocyte , immunology , alveolar macrophage , psoriasis , granulocyte colony stimulating factor , bronchoalveolar lavage , macrophage , pathology , cytokine , chemotherapy , biochemistry , chemistry , in vitro
Pulmonary alveolar proteinosis (PAP) is a rare lung disease. Although whole lung lavage is considered the most effective treatment, not every patient shows a complete response. The case of a young man with PAP in association with psoriasis who underwent frequent whole lung lavage but only achieved remission following treatment with granulocyte‐macrophage colony stimulating factor (GM‐CSF) is reported. His lung problem was complicated by atypical mycobacterial infection, which resolved with treatment. The role of GM‐CSF is discussed.