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The pulmonary and extra‐pulmonary effects of high‐dose formoterol in COPD: A comparison with salbutamol
Author(s) -
Goldkorn Alexandra,
Diotto Patricia,
Burgess Carl,
Weatherall Mark,
Holt Shaun,
Beasley Richard,
Siebers Robert
Publication year - 2004
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2003.00525.x
Subject(s) - medicine , formoterol , salbutamol , copd , pulmonary disease , bronchodilator agents , formoterol fumarate , asthma , intensive care medicine , anesthesia , bronchodilator , budesonide
Objectives: Formoterol, a β 2 agonist with a rapid onset of effect and long duration of action, can be used as maintenance and reliever medication for asthma and COPD. We compared the pulmonary and extra‐pulmonary effects of cumulative doses of formoterol and salbutamol in patients with COPD to assess efficacy and safety. Methodology: In a randomized, double‐blind, cross‐over study, 12 patients with moderate to severe COPD inhaled, via Turbuhaler®, 10 doses of formoterol (total metered dose, 120 µg, equivalent to a 90‐µg delivered dose), salbutamol (total metered dose 2000 µg) or placebo at 2‐min intervals on separate days. The effects on lung function (FEV 1 and PEF), heart rate, blood pressure, oxygen saturation, corrected QT interval (QTc), T‐wave height and plasma potassium were assessed before each dose, 15 min after each dose, and at half‐hourly intervals for 3 h following the final dose. Results: Inhalation of formoterol or salbutamol resulted in significant improvement in lung function (measured 30 min after the last dose) when compared with placebo. There were no clinically important or statistically significant changes in heart rate, QTc, T‐wave height, plasma potassium, oxygen saturation, or systolic and diastolic blood pressures with formoterol or salbutamol. One patient developed ventricular trigeminy after both formoterol and salbutamol. She had had ventricular ectopics on her screening electrocardiogram. Conclusion: Formoterol and salbutamol both produced significant improvement in lung function and were similarly well tolerated in high doses, as might be taken by a patient for relief of COPD symptoms.