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Pancoast's syndrome in a patient with B‐cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement
Author(s) -
Takahashi Fumiyuki,
Ohwada Akihiko,
Higashihara Yoshie,
Yoshioka Yasuko,
Uekusa Toshimasa,
Takahashi Kazuhisa,
Dambara Takashi,
Fukuchi Yoshinosuke
Publication year - 2004
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.2003.00520.x
Subject(s) - lymphoma , medicine , gene rearrangement , antibody , pathology , diffuse large b cell lymphoma , immunoglobulin gene , immunoglobulin heavy chain , gene , immunology , biology , biochemistry
Pancoast's syndrome due to malignant lymphoma is extremely rare. A case of diffuse large B‐cell lymphoma presenting as Pancoast's syndrome is described. A 66‐year‐old man complained of pain and weakness of the right arm, and CXR revealed a right apical lung tumour. Histological findings were consistent with it being a diffuse large cell type lymphoma and Southern blot analysis revealed clonal rearrangement of the immunoglobulin heavy‐chain JH. Thus, the tumour in this patient was diagnosed to be diffuse large B‐cell lymphoma. Malignant lymphoma is an extremely rare cause of Pancoast's syndrome and only five cases have been described. This is the first reported case of Pancoast's syndrome caused by B‐cell lymphoma, which was accurately diagnosed by analysis of gene rearrangement.