Premium
Progressive interstitial pneumonia associated with myelodysplastic syndrome: Implication of superoxide hyperproduction by neutrophils
Author(s) -
TAMAKI Yumi,
SEYAMA Kuniaki,
TAKAHASHI Hideki,
HIRANO Takao,
UEKUSA Toshimasa,
DAMBARA Takashi,
KIRA Shiro,
FUKUCHI Yoshinosuke,
TOMINAGA Shigeru
Publication year - 1997
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/j.1440-1843.1997.tb00092.x
Subject(s) - medicine , superoxide , pneumonia , myelodysplastic syndromes , exertional dyspnea , immunology , interstitial pneumonia , lung , biochemistry , bone marrow , enzyme , chemistry
Interstitial pneumonia and aseptic neutrophilic infiltration in the lung are rare pulmonary manifestations of myelodysplastic syndrome (MDS). We report a patient with progressive interstitial pneumonia associated with MDS. Histological examination of the lung revealed infiltration of atypical haematopoietic cells associated with MDS and diffuse alveolitis with honeycombing. Neutrophils obtained from the patient showed superoxide hyperproduction after stimulation with phagocytosis and phorbol myristate acetate, which might be attributed to the pathogenesis of interstitial pneumonia.