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Malignant diffuse‐type tenosynovial giant cell tumor of the buttock
Author(s) -
Kondo Reiichiro,
Akiba Jun,
Hiraoka Koji,
Hisaoka Masanori,
Hashimoto Hiroshi,
Kage Masayoshi,
Yano Hirohisa
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2012.02838.x
Subject(s) - giant cell , pathology , cd68 , coagulative necrosis , multinucleate , giant cell tumors , clone (java method) , lesion , cd163 , sarcoma , necrosis , giant cell tumor of bone , biology , immunohistochemistry , medicine , anatomy , macrophage , in vitro , genetics , dna , biochemistry
Malignant diffuse‐type tenosynovial giant cell tumor (D‐TSGCT) is an unusual sarcoma. We report a case of malignant D‐TSGCT located in the left buttock. A 58‐year old woman noticed a small mass at her left buttock 3 months previously. The mass tended to enlarge rapidly, and became 6 cm in diameter. Tumor resection was performed. Grossly, the tumor showed a solid growth pattern and whitish appearance with hemorrhage and necrosis. Microscopically, the tumor was composed of a proliferation of short spindle and oval mononucleated cells with numerous osteoclast‐like multinucleated giant cells, which occasionally showed coagulative necrosis. In addition, tumor cells had high mitotic activity and atypical mitoses. Immunohistochemically, the mononucleated cells were positive for CD163 and focally positive for CD68 (clone KP‐1 and PG‐M1), CD4, smooth muscle actin and S100 protein. Osteoclast‐like multinucleated giant cells were positive for CD68 (clone KP‐1 and PG‐M1) and CD4. Pulmonary metastases were found 6 months after the operation. These findings indicate that this lesion is consistent with malignant D‐TSGCT.