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High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma
Author(s) -
Yoshida Maki,
Ichikawa Ayako,
Miyoshi Hiroaki,
Takeuchi Masanori,
Kimura Yoshizo,
Nino Daisuke,
Ohshima Koichi
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2012.02835.x
Subject(s) - lymphoma , in situ hybridization , follicular lymphoma , pathology , pathogenesis , incidence (geometry) , fluorescence in situ hybridization , follicular phase , chromogenic in situ hybridization , medicine , immunohistochemistry , biology , gene expression , gene , biochemistry , physics , optics , chromosome
t(14;18) is a common cytogenetic abnormality in B‐cell lymphoma, especially in follicular lymphoma (FL), but is rarely seen in Hodgkin's lymphoma (HL). However, due to the small number of cases, the incidence of t(14;18) in HL associated with FL remains unclear. In this study, we applied chromogenic in situ hybridization and fluorescence in situ hybridization for t(14;18) on paraffin‐embedded tissue from four HL associated with FL cases and 11 HL cases without a history of FL for comparison. t(14;18) was present in all of the three successfully‐tested HL associated with FL cases and one case without a history of FL. The frequency of t(14;18) was significantly high in HL associated with FL ( p = 0.013). All Hodgkin's and Reed‐Sternberg (HRS) cells having t(14;18) showed immunoreactivity for BCL2 and were negatively stained for nuclear factor‐κB (NF‐κB), even in Epstein‐Barr virus (EBV)‐infected cases. However, HRS cells without t(14;18) showed BCL2 and NF‐κB immunoreactivity in 33% and 57% of cases, respectively. There was an inverse correlation between t(14;18) and NF‐κB. In conclusion, we assume the incidence of t(14;18) in HL associated with FL is higher than previously believed and BCL2 expression derived from t(14;18) may play a role in the pathogenesis of HL associated with FL.