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Critical multi‐organ emboli originating from collapsed, vulnerable caseous mitral annular calcification
Author(s) -
Matsuyama Takaaki,
IshibashiUeda Hatsue,
Ikeda Yoshihiko,
Nagatsuka Kazuyuki,
Miyashita Kotaro,
Amaki Makoto,
Kanzaki Hideaki,
Kitakaze Masafumi
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2012.02826.x
Subject(s) - calcification , abnormality , medicine , asymptomatic , stenosis , embolic stroke , cardiology , pathology , stroke (engine) , radiology , ischemic stroke , ischemia , mechanical engineering , psychiatry , engineering
Mitral annular calcification (MAC) is a generally asymptomatic abnormality found commonly in aged hearts. Some clinical studies have suggested that MAC should be considered an independent risk factor for stroke; however, whether the abnormality is indeed a risk factor remains controversial. We report a case in which debris from a vulnerable caseous MAC contributed to lethal embolisms in multiple organs. Postmortem examination revealed that caseous materials originating from a collapsed MAC were trapped in stenosed atherosclerotic cerebral and coronary arteries. Our findings support the notion at that subtle debris from collapsed vulnerable MACs can trigger major and even lethal embolic events in patients with severe atherosclerotic stenosis in vital organs.