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Expression of β‐tubulin isotypes in classical Hodgkin's lymphoma
Author(s) -
Choi JungWoo,
Lee JuHan,
Kim YoungSik
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2011.02785.x
Subject(s) - isotype , tubulin , immunohistochemistry , microtubule , biology , lymphoma , cancer research , microbiology and biotechnology , pathology , immunology , antibody , medicine , monoclonal antibody
Microtubules consist of heterodimers of α‐ and β‐tubulin. Aberrant expression of specific β‐tubulin isotype is associated with resistance to chemotherapy in malignant tumors. In this study, we examined the expressions of β‐tubulin isotypes in classical Hodgkin's lymphoma (cHL) by immunohistochemistry. Among the β‐tubulin isotypes, class II β‐tubulin (31/34, 91%) was most frequently overexpressed in the cytoplasm of almost all Hodgkin's and Reed‐Sternberg (HRS) cells, followed by class I β‐tubulin (18/34, 53%) and class III β‐tubulin (12/34, 35%). Class IV β‐tubulin was not expressed in any cHL case. Class I β‐tubulin was expressed in the background lymphoid cells as well as the HRS cells. Thus, our results indicate that class II β‐tubulin may be very useful for immunohistochemical diagnosis of cHL, and provide valuable information for the potential application of β‐tubulin isotype‐specific targeting.