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Breast cancer resistance protein expression is associated with early recurrence and decreased survival in resectable pancreatic cancer patients
Author(s) -
Lee Sang Hyub,
Kim Haeryoung,
Hwang JinHyeok,
Lee Hye Seung,
Cho Jai Young,
Yoon YooSeok,
Han HoSeong
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2011.02772.x
Subject(s) - abcg2 , multidrug resistance associated protein 2 , immunohistochemistry , medicine , pancreatic cancer , clinical significance , cancer , breast cancer , oncology , perineural invasion , multiple drug resistance , atp binding cassette transporter , cancer research , pathology , biology , drug resistance , transporter , biochemistry , microbiology and biotechnology , gene
The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains dismal even after complete resection, with most recurrences occurring within 1–2 years postoperatively. Adenosine triphosphate (ATP)‐binding cassette (ABC) transporters have been demonstrated to play major roles in multidrug resistance (MDR) of cancers. In this study, we evaluated the expression statuses and the clinical significance of MDR1 (ABCB1), MDR‐associated proteins (MRPs/ABCC) 1, 2 and 3, and breast cancer resistance protein (BCRP/ABCG2) in 67 surgically resected PDACs by immunohistochemistry. MDR1, MRP1, MRP2, MRP3 and BCRP were expressed in 35 (52.2%), 56 (83.6%), 61 (91.0%), 49 (73.1%) and 49 (73.1%) out of 67 cases, respectively. The expression statuses of the MDR‐related proteins were positively correlated with each other ( P < 0.05). Tumors expressing MRP1 ( P = 0.015), MRP2 ( P = 0.022) and MRP3 ( P < 0.001) demonstrated more frequent perineural invasion. MDR1 expression was significantly correlated with lymphatic invasion ( P = 0.047). High BCRP expression in PDAC was a significant prognostic factor for early tumor recurrence (HR = 2.43, P = 0.003) and poor survival (HR = 2.63, P = 0.001). MDR‐related proteins are frequently expressed in PDAC, and high BCRP expression is a significant independent predictor for early recurrence and poor survival. Immunohistochemical analysis for BCRP expression in PDAC may be a useful test in identifying a subgroup of patients with a poor prognosis.