Premium
FOXP3 + regulatory and TIA‐1 + cytotoxic T lymphocytes in HIV‐associated Hodgkin lymphoma
Author(s) -
Kiyasu Junichi,
Aoki Ryosuke,
Tanaka Paula Yurie,
Pracchia Luis Fernando,
Calore Edenilson Eduardo,
Perez Nilda Maria,
Kimura Yoshizo,
Niino Daisuke,
Sugita Yasuo,
Takayanagi Ryoichi,
Abe Yasunobu,
Matsuoka Masao,
Ohshima Koichi
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2011.02754.x
Subject(s) - lymphoma , cytotoxic t cell , pathogenesis , cd8 , immunology , epstein–barr virus , foxp3 , lymphocyte , negativity effect , staining , medicine , virus , virology , biology , antigen , pathology , immune system , in vitro , psychology , social psychology , biochemistry
Human immunodeficiency virus (HIV) infects CD4 + lymphocytes, leading to a development of malignant lymphomas, such as HIV‐associated Hodgkin Lymphoma (HIV‐HL). This study aimed to assess the differences in cellular composition of the inflammatory reactive background of HIV‐HLs. We examined infiltrating T lymphocytes, specifically regulatory T cells, cytotoxic cells, Epstein‐Barr virus (EBV) related antigens and HIV‐receptor CCR5. In all HIV‐HL cases, Hodgkin and Reed‐Sternberg (HRS) cells showed EBER1 expression, LMP‐1 staining positivity and EBNA‐2 staining negativity, except for one case which showed LMP‐1 staining negativity. Our histological findings indicate the percentage of CD8 + , TIA‐1 + lymphocytes was significantly higher in HIV‐HL than in non‐HIV‐HL cases ( P < 0.05). On the other hand, the percentage of CD4 + , FOXP3 + lymphocytes was significantly lower in HIV‐HL than in non‐HIV‐HL cases ( P < 0.05) but present. The percentage of CCR5 + lymphocytes was significantly lower in HIV‐HL than in non‐HIV‐HL cases ( P < 0.05). Usually, CD4 + and CCR5 + lymphocytes are reported to be rarely detected in HIV‐associated non‐Hodgkin lymphomas, but the presence of CD4 + and/or FOXP3 + lymphocytes may be implicated in the pathogenesis of HL. In addition, although additional CD8 + lymphocytes are probably not EBV‐LMP specific cytotoxic T‐cells, these lymphocytes may also well be involved in the pathogenesis of HIV‐HL.