Premium
Epstein–Barr virus‐associated lymphoproliferative disorder presenting with classical Hodgkin lymphoma and developing as peripheral T‐cell lymphoma 9 years later: A case report of composite lymphoma
Author(s) -
Oka Kuniyuki,
Nagayama Reizo,
Iijima Shigeruko,
Yonekawa Nobuo,
Hirosawa Kunihiro,
Yatabe Yasushi,
Mori Naoyoshi
Publication year - 2011
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2011.02723.x
Subject(s) - cd30 , lymphoma , peripheral t cell lymphoma , pathology , medicine , lymph node , classical hodgkin lymphoma , virus , lymphoproliferative disorders , epstein–barr virus , t cell lymphoma , epithelioid cell , anaplastic large cell lymphoma , t cell , hodgkin's lymphoma , immunology , immunohistochemistry , hodgkin lymphoma , immune system
We describe a patient who was diagnosed with classical Hodgkin lymphoma (CHL) at 67‐years‐old and peripheral T‐cell lymphoma, not otherwise specified (PTCL) at 76‐years‐old, and died 5 months later. Both tumors showed prominent epithelioid cell reaction admixed with neoplastic cells. Hodgkin and Reed–Sternberg cells in the swollen lymph node were positive for CD30 and EBV‐encoded RNA (EBER). PTCL cells in the skin tumor were positive for cytoplasmic CD3ε, CD4 and EBER. A rearrangement band of the T‐cell receptor gene was detected in the skin tumor. This case is the first documented EBV‐associated composite lymphoma composed of CHL and PTCL. The patient may show the possibility that both EBV infection and/or immunodeficiency induce the development of CHL and PTCL.