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Combined adenomatoid tumor and well differentiated papillary mesothelioma of the omentum
Author(s) -
Hatano Yuichiro,
Hirose Yoshinobu,
Matsunaga Kengo,
Kito Yusuke,
Yasuda Ichiro,
Moriwaki Hisataka,
Osada Shinji,
Yoshida Kazuhiro,
Hara Akira
Publication year - 2011
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2011.02720.x
Subject(s) - adenomatoid tumor , mesothelioma , pathology , greater omentum , medicine , anatomy , immunohistochemistry
Herein is reported a highly rare case of combined adenomatoid tumor and well differentiated papillary mesothelioma of the omentum. A 45‐year‐old Japanese man was incidentally found to have a mesenteric mass during abdominal ultrasonography. Grossly, a well‐circumscribed and non‐encapsulated tumor, measuring 24 × 23 × 22 mm, was located in the omentum with no obvious invasion to the surrounding stomach and pancreas. Microscopically, the tumor consisted of two histological distinct components; the majority of it showed irregular arrangement of numerous cysts lined by a single layer of flattened or epithelioid cells and the multifocal minor component exhibited prominent papillary protrusions lined by a single layer of cuboidal cells with relatively uniform nucleus. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin (AE1/AE3), vimentin, calretinin, D2‐40 and WT‐1, and negative for epithelial membrane antigen (EMA), desmin, S‐100 protein and CD68. Ki‐67 labeling index of the tumor cells was <5%. The postoperative course was uneventful, though he has not received any adjuvant therapy. Despite the rarity, recognition of such combined cases of mesothelial lesions is important to prevent overdiagnosis.