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Coexistence of primary pulmonary Hodgkin lymphoma and gastric MALT lymphoma associated with Epstein‐Barr virus infection: A case report
Author(s) -
Oka Kuniyuki,
Shiaga Mayumi,
Nagayama Reizo,
Kashimura Hiroshi,
Yonekawa Nobuo,
Tatebe Sho,
Kuraoka Setsuo,
Yatabe Yasushi,
Mori Naoyoshi
Publication year - 2010
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2010.02554.x
Subject(s) - cd15 , cd30 , pathology , lymphoma , medicine , nodular sclerosis , epstein–barr virus , cd20 , gastric lymphoma , virus , marginal zone , malt lymphoma , b cell , hodgkin lymphoma , immunology , biology , cd34 , antibody , genetics , stem cell
We describe a 66‐year‐old woman with Epstein‐Barr virus‐associated lymphoproliferative disorder with lung and gastric tumors. We identified two lung tumors measuring 13 and 20 mm in diameter that consisted of CD30‐, CD15‐, and CD20‐positive Hodgkin‐ and Reed‐Sternberg‐like cells and heterogeneous cellular infiltrates in a pronounced nodular pattern, with necrosis and vasculitis, diagnosed as nodular sclerosis classical Hodgkin lymphoma. A gastric tumor showed low‐grade extranodal marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue type. Neoplastic cells in all tumors expressed Epstein‐Barr virus‐encoded RNA based on in situ hybridization. The present case is a rare composite lymphoma arising from different extranodal organs, associated with EBV infection. Her medical history included gamma‐knife therapy for clinical diagnosis with a suspicion of cerebral lymphoma.