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Simple quantitative analysis of asbestos body using the sediment of formalin injected into surgically resected lung cancers
Author(s) -
Sakai Yasuhiro,
Ohbayashi Chiho,
Itami Hiroe,
Kajimoto Kazuyoshi,
Sakuma Toshiko,
Uchino Kazuya,
Yoshimura Masahiro,
Matsumoto Shoji,
Idei Yuka,
Oka Teruaki
Publication year - 2010
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2009.02488.x
Subject(s) - asbestos , lung , lung cancer , medicine , pathology , materials science , metallurgy
A simple screening method for quantitatively analyzing asbestos bodies that can be carried out even in community hospitals, is needed in order for laborers and neighborhoods in the vicinity of asbestos factories to apply for compensation for asbestos‐related injury. Eighty‐eight consecutive cases of surgically resected primary lung cancer were analyzed for asbestos bodies using two methods, and the correlation between them was statistically examined. The first was the conventional technique using lung tissue digestion and phase‐contrast scanning, and the second was the authors' method using light microscopy to scan the sediment of formalin‐injected lung specimens. The overall correlation coefficient of the concentration of asbestos bodies between the authors' method (C AB/SED ) and the conventional method (C AB/DLT ) was 0.4576, a weak statistically significant correlation; in patients with occupational asbestos exposure, however, the correlation coefficient was 0.7341. Despite the cost, it may be prudent to use the conventional method under the present law for patients with C AB/SED ≥3.5/mL. C AB/DLT >3000/g dry lung tissue when C AB/SED is ≥3.5/mL suggests the potential for the accumulation of asbestos absorption by lung tissue.