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Chromosomal abnormalities of clear cell renal cell carcinoma: Frequent gain of chromosome 7
Author(s) -
Kuroda Naoto,
Tamura Masato,
Shiotsu Tomoyuki,
Nakamura Shoichiro,
Taguchi Takahiro,
Tominaga Akira,
Hes Ondrej,
Michal Michal,
Kawada Chiaki,
Shuin Taro,
Lee GangHong
Publication year - 2010
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2009.02467.x
Subject(s) - chromosome , renal cell carcinoma , karyotype , chromosome 7 (human) , biology , papillary renal cell carcinomas , pathology , chromosome abnormality , chromosome 9 , abnormality , clear cell renal cell carcinoma , genetics , medicine , gene , psychiatry
Gain of chromosome 7 is well known to be a characteristic abnormality of papillary renal cell carcinoma (RCC). The purpose of the present study was to perform cytogenetic analysis of G‐band karyotype in 16 clear cell RCC obtained from nephrectomy. The age of patients ranged from 50 to 79 years and the tumor size in largest dimension ranged from 1.8 to 6.2 cm. As a result, the structural abnormality of chromosome 3 was most frequently observed (eight clones). Loss of chromosome 3 and gain of chromosome 7 followed (four clones). Among four clones showing gain of chromosome 7, two were associated with the abnormality of chromosome 3 and the remaining two were devoid of the abnormalities of chromosome 3. In addition, none of all four tumors showing gain of chromosome 7 demonstrated any foci of papillary growth pattern. The present study shows that gain of chromosome 7 is not exclusive to papillary RCC, but it can be found in clear cell RCC as well, and this finding may represent a diagnostic pitfall in distinguishing clear cell RCC from papillary RCC.