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Urothelial carcinoma of the renal pelvis with rhabdoid features
Author(s) -
Fukumura Yuki,
Fujii Hiroaki,
Mitani Keiko,
Sakamoto Yoshiro,
Matsumoto Toshiharu,
Suda Koichi,
Yao Takashi
Publication year - 2009
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2009.02373.x
Subject(s) - pathology , vimentin , eosinophilic , loss of heterozygosity , renal pelvis , lesion , biology , carcinoma , medicine , immunohistochemistry , anatomy , allele , urinary system , biochemistry , gene
Reported herein is the case of a 70‐year‐old man with high grade urothelial carcinoma (UC) with rhabdoid features of the renal pelvis. For the most part, the tumor was composed of pleomorphic, non‐cohesive round tumor cells with abundant cytoplasm. In situ high‐grade UC composed of cohesive tumor cells was seen only in a small portion. Pleomorphic dyscohesive tumor cells often showed rhabdoid features, containing eosinophilic inclusions. These pleomorphic/rhabdoid tumor cells were immunohistochemically positive for vimentin but negative for cytokeratins, CD45, CD20, CD79a, CD3, CD45RO, CD38, and CD138. Loss of heterozygosity (LOH) analysis demonstrated identical allelic losses as well as additional allelic losses for the dyscohesive and cohesive UC lesion, indicating that these two lesions originated from a single clonal lesion.