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Transformation from follicular lymphoma to high‐grade B‐cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c‐MYC and BCL‐2, and light‐chain switch
Author(s) -
Mannouji Kiyohito,
Tasaka Taizo,
Akiyama Takashi,
Irei Isao,
Sano Fuminori,
Matsuhashi Yoshiko,
Wada Hideho,
Tohyama Kaoru,
Sugihara Takashi,
Sadahira Yoshito
Publication year - 2009
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2009.02361.x
Subject(s) - chromosomal translocation , follicular lymphoma , lymphoma , immunoglobulin light chain , transformation (genetics) , downregulation and upregulation , cancer research , malignant transformation , leukemia , follicular phase , immunohistochemistry , gene rearrangement , pathology , biology , gene , medicine , antibody , immunology , genetics
Transformation from follicular lymphoma (FL) to high‐grade B‐cell lymphoma/leukemia (BLL) has been reported in patients with additional translocations involving the c‐MYC gene. The previously reported cases were related to t(8;14) and t(8;22) but not to t(2;8). Herein is reported an FL that terminated in BLL following additional t(2;8). In accordance with previous reports, increased expression of c‐MYC was observed in the present case but, interestingly, BCL‐2 expression was inversely decreased after the transformation. In addition, the cell‐surface immunoglobulin light‐chain of lymphoma cells was initially κ type and was then gradually replaced with the λ type after transformation. Downregulation of BCL‐2 and light‐chain switch have rarely been reported in previous cases of FL transformation involving c‐MYC , suggesting that additional t(2;8) translocation may play a role in these events.