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Follicular lymphoma with marked infiltration of eosinophils
Author(s) -
Shiraishi Junichi,
Nakagawa Yasunori,
Kurata Morito,
Yamamoto Kohei,
Abe Yu,
Toyoda Yukitoshi,
Suzuki Kenshi,
Kitagawa Masanobu,
Takemura Tamiko
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2008.02296.x
Subject(s) - pathology , follicular lymphoma , medicine , germinal center , infiltration (hvac) , lymphoma , follicular hyperplasia , histology , lymph , lymph node , eosinophil , immunohistochemistry , b cell , immunology , physics , asthma , antibody , thermodynamics
Eosinophilia and tissue infiltration by eosinophils are frequent findings in Hodgkin lymphoma, but they are extremely rare in B‐cell lymphoma. Reported herein is a case of follicular lymphoma with extensive lymph node infiltration by eosinophils. The patient was a 71‐year‐old woman who had a mass in the vicinity of the pancreas found on routine ultrasonography. Subsequent CT indicated several enlarged abdominal lymph nodes, although superficial lymph nodes were not palpable. Two swollen mesenteric lymph nodes were excised to determine the cause of the lymphadenopathy. Histology indicated extensive infiltration of numerous eosinophils to the interfollicular area, especially in the dilated sinuses. The lymphoid follicles were relatively small, had inconspicuous germinal centers, and were scattered between dilated sinuses. Based on the histology, immunohistochemistry, and chromosomal abnormality, a diagnosis of follicular lymphoma was made. Expression of interleukin‐3 (IL‐3), IL‐5, eotaxin, eotaxin‐2, and eotaxin‐3 was investigated on reverse transcription–polymerase chain reaction of the lymph node tissue, but none of the mRNA expression levels were elevated. This was a unique case of follicular lymphoma with extensive eosinophil infiltration, and to the best of the authors' knowledge this is the first such case ever reported.