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Distribution of HPV genotypes in uterine cervical lesions in Yanbian, northern China
Author(s) -
Zhao Yiwei,
Lin Hai,
Shen Danhua,
Xuan Yanhua,
Lin Zhenhua
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2008.02283.x
Subject(s) - cervix , adenocarcinoma , medicine , cervical cancer , cervical intraepithelial neoplasia , genotype , biopsy , hpv infection , pathology , oncology , cancer , biology , gene , biochemistry
The aim of the present study was to investigate the distribution of HPV genotypes in uterine cervical lesions in Yanbian, northern China. HPV‐DNA chip (oligonucleotide microarray) and cervical biopsy were used for 322 women in 1998–2005. All the normal cervical epithelia were negative for HPV. The positive rate of high‐risk HPV was 33.9% in cervical intra‐epithelial neoplasia (CIN)‐1, 51.6% in CIN‐2, 57.7% in CIN‐3, 66.7% in cervical glandular intra‐epithelial neoplasia (CGIN), 91.7% in squamous cell carcinoma (SCC), and 78.6% in adenocarcinoma. HPV‐16 was the major type in all CIN and SCC cervical lesions, but in cervical adenocarcinoma HPV‐18 was the most common type, and HPV‐16 was the second most common type. Several cases of CIN‐3, SCC and adenocarcinoma had multiple types of HPV, but there was none in CIN‐1/2. In summary, HPV‐16 is the type most frequently involved in the development of SCC of the cervix, and this may be helpful for the prediction of the development and progress of CIN‐2/3, whereas both HPV‐18 and ‐16 play a prominent role in the development of adenocarcinoma and CGIN of the cervix in Yanbian, northern China.