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Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis
Author(s) -
Inoue Akemi,
Moriya Hiromitsu,
Katada Natsuya,
Tanabe Satoshi,
Kobayashi Nobuyuki,
Watanabe Masahiko,
Okayasu Isao,
Ohbu Makoto
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2008.02279.x
Subject(s) - lymphangiogenesis , medicine , immunohistochemistry , vascular endothelial growth factor , pathological , vascular endothelial growth factor c , pathology , esophageal squamous cell carcinoma , lymphatic vessel , lymphatic system , lymph node , metastasis , vegf receptors , oncology , carcinoma , vascular endothelial growth factor a , cancer
The clinical and pathological significance of intratumoral lymphangiogenesis (ITL) with human esophageal squamous cell carcinomas (ESCC) remains unclear, as does the role of signaling molecules such as vascular endothelial growth factor (VEGF)‐A,C, platelet‐derived growth factor (PDGF)‐A, and p53, in the regulation of ITL. Lymphatic vessel density (LVD) was significantly increased in VEGF‐A and VEGF‐C immunohistochemical score 1 and 2–3 groups as compared to the score 0 group and also with high of VEGF‐A, VEGF‐C and PDGF‐A mRNA expression. Both LVD and blood vessel density (BVD) were significantly greater in the p53 gene mutant group than in the wild‐type group. Lymph node metastasis was significantly more frequent with than without ITL and Kaplan–Meier analysis indicated a significantly poorer prognosis. Multivariate analysis using Cox proportional hazard method showed that invasion depth, lymph node metastasis and ITL were independent prognostic factors.