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Thymic epithelial cells expressed unusual follicular dendritic cell markers: Thymic extranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue
Author(s) -
Masunaga Atsuko,
Iwamoto Sanju,
Nakamura Hisayoshi,
Usuda Rhosuke,
Masuda Mikio,
Suzuki Shuichi,
Miyazaki Akira,
Suzuki Takashi,
Mitsuya Toshiyuki,
Yoshitake Tsuyoshi
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2008.02243.x
Subject(s) - cytokeratin , pathology , biology , immunohistochemistry , lymphatic system , marginal zone , epithelium , germinal center , lymphoma , follicular dendritic cells , immunoelectron microscopy , b cell , t cell , antibody , medicine , immunology , immune system , antigen presenting cell
Described herein is a case of thymic extranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue. Using immunohistochemical double staining it was found that most of the thymic lymphoid follicles in this case possessed cytokeratin‐positive and follicular dendritic cell (FDC) marker‐positive cells. Moreover, using immunoelectron microscopy it was confirmed that some of the double‐positive cells were thymic epithelial cells. The candidate of cytokeratin subtype expressed on the double‐positive cells was cytokeratin 1 (CK1), which was expressed only by the epithelium of Hassall's corpuscles in thymuses from age‐matched patients with myasthenia gravis. The present case indicates a possibility that some thymic epithelial cells become FDC, although it was uncertain whether they were derived from the epithelia of Hassall's corpuscles or whether they were at the same differentiation stage as Hassall's corpuscles.