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Primary mucosa‐associated lymphoid tissue lymphoma of the prostate: Tumor relapse 7 years after local therapy
Author(s) -
Li Chunmei,
Hibino Mitsunobu,
Komatsu Hirokazu,
Sakuma Hidenori,
Sakakura Takeshi,
Ueda Ryuzo,
Eimoto Tadaaki,
Inagaki Hiroshi
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2007.02210.x
Subject(s) - malt lymphoma , medicine , lymphoma , pathology , prostate , mucosa associated lymphoid tissue , lymphatic system , hyperplasia , lesion , lymphoid hyperplasia , cancer
Primary mucosa‐associated lymphoid tissue (MALT) lymphoma of the prostate is rare, and only five cases have been reported. Reported herein is a new case that has involved a 9 year follow up. A 79‐year‐old man was treated with transurethral resection (TUR) for a mass of the right prostatic lobe, and followed up under a diagnosis of benign prostatic hyperplasia with atypical lymphoid infiltration. Seven years later TUR was again performed for a right lobe mass. The lesion was diagnosed as a relapsed MALT lymphoma after detailed histological and immunoglobulin heavy chain gene analyses of the initial and relapsed lesions. Interestingly, lymphoepithelial lesions were observed only infrequently in this tumor. The API2‐MALT1 fusion, a gene alteration specific to MALT lymphoma, was absent. The patient had stage IA disease at the time of tumor relapse, and has been alive and well for the 2 years after the second TUR. The present case suggests that despite tumor recurrence, prostatic MALT lymphoma is indolent, and function‐preserving therapy is warranted.