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Carcinoid tumor of the renal pelvis: Consideration on the histogenesis
Author(s) -
Kuroda Naoto,
Katto Kazunobu,
Tamura Masato,
Shiotsu Tomoyuki,
Hes Ondrej,
Michal Michal,
Nagashima Yoji,
Ohara Masahiko,
Hirouchi Takashi,
Mizuno Keiko,
Hayashi Yoshihiro,
Lee GangHong
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2007.02188.x
Subject(s) - renal pelvis , pathology , histogenesis , carcinoid tumors , anatomy , kidney , biology , medicine , immunohistochemistry , urinary system
Carcinoid tumor of the renal pelvis is an extremely rare neoplasm and only two cases have been previously reported in the English‐language literature. Reported herein is a third case of carcinoid tumor arising in the renal pelvis. The tumor extending from the left renal pelvis into the left kidney was incidentally found in a 55‐year‐old Japanese woman. Macroscopically, the tumor was predominantly located in the dilated renal pelvis and was grayish‐white on cut surface. Microscopically, neoplastic cells proliferated with a ribbon‐like, trabecular, tubular and solid pattern. Furthermore, the tumor focally invaded the kidney parenchyma. No precursor lesion of neuroendocrine tumor was observed in the peripheral urothelial epithelium. Neither urothelial carcinoma nor teratoma component was observed within the tumorous mass. The cytoplasm of neoplastic cells was focally positive for Grimelius stain and focally positive for chromogranin A and synaptophysin. However, no neoplastic cells reacted with cytokeratins 7 and 20. Ultrastructurally, neoplastic cells contained dense core granules in the cytoplasm. Urologists and pathologists should recognize that carcinoid tumor may arise from the renal pelvis.