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Immunohistochemical expression of TTF‐1 in various cytological subtypes of primary lung adenocarcinoma, with special reference to intratumoral heterogeneity
Author(s) -
Maeshima Akiko M.,
Omatsu Mutsuko,
Tsuta Koji,
Asamura Hisao,
Matsuno Yoshihiro
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2007.02185.x
Subject(s) - immunohistochemistry , pathology , adenocarcinoma , lung , thyroid transcription factor 1 , cell , phenotype , biology , medicine , cancer , gene , genetics , biochemistry
The immunohistochemical expression of thyroid transcription factor‐1 (TTF‐1) was investigated in various cytological subtypes of primary lung adenocarcinoma, with special reference to intratumoral heterogeneity. Three groups were categorized according to cytological subtype: group A, adenocarcinomas with either a Clara cell and/or type II epithelial cell component (Clara/type II) or a mixed Clara/type II and bronchial surface epithelial cell component (BSE) (mCB), in addition to other components; group B, adenocarcinomas with components including either BSE, a goblet cell component (GOB) or a mixed BSE and GOB component (mBG), and lacking Clara/type II or mCB; group C, adenocarcinomas with only a poorly differentiated component (POR). In group A all Clara/type II, mCB, BSE and the majority of POR were TTF‐1 positive. In group B the majority of BSE, POR and all GOB were TTF‐1 negative. BSE and POR in both groups had a different phenotype, possibly reflecting their different natural history. In group C 80% of cases were TTF‐1 positive, suggesting that the majority were derived from group A tumors.