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Clinicopathological study of invasive ductal carcinoma with large central acellular zone: Special reference to magnetic resonance imaging findings
Author(s) -
Yamaguchi Rin,
Furusawa Hidemi,
Nakahara Hiroshi,
Inomata Masuko,
Namba Kiyoshi,
Tanaka Maki,
Ohkuma Kazuaki,
Tayama Kohsuke,
Fujii Teruhiko,
Yano Hirohisa,
Kage Masayoshi,
Kojiro Masamichi
Publication year - 2008
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2007.02184.x
Subject(s) - magnetic resonance imaging , pathology , medicine , lymph , contrast enhancement , radiology
Invasive ductal carcinoma (IDC) with central acellular zone is sometimes encountered, but its clinicopathological features have not yet been fully investigated. The clinicopathological features of 10 resected cases of IDC with a large central acellular zone were investigated. The tumor size ranged from 6 to 28 mm with a mean of 14.3 ± 6.9 mm. Contrast‐enhanced magnetic resonance imaging (MRI) showed a ring‐like appearance in the tumor. Sagittal fat‐suppressed T2‐weighted MRI had very high to intermediate signal intensity in a central area. Histologically, cancer tissue was located in the periphery of the tumor with a ring‐like pattern and a large central area was occupied by acellular amorphous tissue that was strongly stained by alcian blue. Lymph vessel permeation was seen in eight cases. Among the tumors with focal enhancement in the central areas >1 cm in diameter on contrast MRI, marked increase of microvessel was observed in the enhanced spot. The mean of p53 and Ki‐67 labeling indices was 56.2% and 36.3%, respectively. IDC with a large central acellular zone presenting with characteristic MRI should be noted as a new morphological entity.