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Histopathological bone marrow changes after reduced‐intensity hematopoietic stem cell transplantation for follicular lymphoma involving bone marrow
Author(s) -
Maeda Takashi,
Shiozawa Eisuke,
Saito Bungo,
Usui Takako,
Nakashima Hidetoshi,
Hattori Norimichi,
Adachi Daisuke,
Yanagisawa Kouji,
Kawakami Keiichiro,
Nakamaki Tsuyoshi,
Tomoyasu Shigeru,
YamochiOnizuka Toshiko,
Takimoto Masafumi,
Ota Hidekazu
Publication year - 2007
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2007.02110.x
Subject(s) - bone marrow , lymphoma , pathology , medicine , haematopoiesis , stem cell , transplantation , follicular lymphoma , hematopoietic stem cell transplantation , biology , genetics
Allogeneic stem cell transplantation (allo‐SCT) is used as curative therapy for malignant lymphoma, and reduced‐intensity hematopoietic stem cell transplantation (RIST) is sometimes performed to avoid the toxicity and mortality associated with myeloablative allo‐SCT. RIST is generally preferred for elderly patients with malignant lymphoma. A 62‐year‐old woman with follicular lymphoma (FL) involving bone marrow (BM) suffered relapse after autologous SCT. RIST was performed; cells were from an unrelated, fully human leukocyte antigen‐matched donor. To study the hematopoietic reconstitution, BM biopsy specimens that were obtained at different times after RIST, were evaluated. Engraftment of donor cells was observed on days 19 and 48 after RIST, and residual FL in BM had completely disappeared by day 73 after RIST. This is the first report to document histological BM regeneration after RIST and disappearance of FL involving the BM.