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Bcl2‐negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 or p53 expression
Author(s) -
Guo Ying,
Karube Kennosuke,
Kawano Riko,
Suzumiya Junji,
Takeshita Morishige,
Kikuchi Masahiro,
Huang GaoSheng,
Li Qing,
Ohshima Koichi
Publication year - 2007
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2006.02072.x
Subject(s) - bcl6 , chromosomal translocation , pathogenesis , immunohistochemistry , fluorescence in situ hybridization , biology , cancer research , follicular lymphoma , lymphoma , apoptosis , gene , in situ hybridization , gene expression , microbiology and biotechnology , immunology , genetics , antibody , b cell , germinal center , chromosome
Bcl2 is an important protein involved in the pathogenesis of follicular lymphoma (FL). However, approximately 10% of FL cases do not express Bcl2. The present study was designed to compare gene aberrations, prosurvival gene expression, apoptosis and proliferation rates in Bcl2‐positive and ‐negative FL cases. Bcl2 translocation and Bcl6 translocation were detected and compared using fluorescence in situ hybridization (FISH). A tendency for Bcl6 translocation to occur was found more frequently in Bcl2‐negative FL than in the Bcl2‐positive cases. The expression of Bcl‐X, BAX, p53, Bcl6 was analyzed by immunohistochemistry. Bcl2 family proteins Bcl‐X and BAX were expressed similarly in the two FL types. In some cases of Bcl2‐negative FL there was high expression of Bcl6 or p53 but no such Bcl2‐positive FL cases were detected. Furthermore, there was an inverse relationship between the expression of Bcl6 and p53. These results indicate that the Bcl6 translocation occurs more frequently in Bcl2‐negative FL. Furthermore, other prosurvival proteins such as p53 and Bcl6 may play an important role in the pathogenesis of Bcl2‐negative FL.