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Angiogenic factors in normal endometrium and endometrial adenocarcinoma
Author(s) -
Saito Mayumi,
Sato Yuichi,
Watanabe Jun,
Kuramoto Hiroyuki,
Kaba Sadayuki,
Fukuda Toshio
Publication year - 2007
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2006.02071.x
Subject(s) - endometrium , angiogenesis , adenocarcinoma , vascular endothelial growth factor , immunohistochemistry , endoglin , pathology , cd34 , angiopoietin receptor , menstrual cycle , medicine , biology , cancer , vegf receptors , stem cell , hormone , genetics
In the endometrium, angiogenesis plays important roles not only in tumor growth but also in the menstrual cycle. The purpose of the present paper was to investigate immunohistochemically the correlation between angiogenic factor expression and angiogenic score in normal and neoplastic endometrium. Immunohistochemical staining for vascular endothelial growth factor (VEGF), angiopoietin (Ang)‐1, Ang2, Tie2, CD34 and CD105 was performed on formalin‐fixed and paraffin‐embedded tissues from 31 normal endometrium and 85 endometrial adenocarcinoma. VEGF, Ang1, Ang2 and Tie2 expression was localized in the cytoplasm of glandular and tumor cells. The levels of each angiogenic factor were different in the phases of the menstrual cycle and each layer of normal endometrium. In general, VEGF and Tie2 expression was higher in adenocarcinoma than in normal epithelial cells. Conversely, Ang1 and Ang2 expression was higher in normal epithelium than in adenocarcinoma. The angiogenic score (CD105/CD34) tended to be higher in the adenocarcinoma than in the normal epithelium. It is suggested that the angiogenic pathway and the role of these factors seem to differ between normal tissue and carcinoma of the endometrium.