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Immunohistochemical study of the relationship between Ki‐67 labeling index of proliferating cells of gynecomastia, histological phase and duration of disease
Author(s) -
Kono Seishi,
Kurosumi Masafumi,
Simooka Hanako,
Kawanowa Kaori,
Ninomiya Jun,
Takei Hiroyuki,
Suemasu Kimito,
Kuroda Yoshikazu
Publication year - 2006
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2006.02025.x
Subject(s) - gynecomastia , immunohistochemistry , medicine , ki 67 , pathology , estrogen , hormone , lesion , endocrinology
Gynecomastia is a benign proliferative lesion caused by various etiological factors and may result from a relative imbalance between serum estrogen and androgen levels. The histological alterations are similar, and gynecomastia can progress from a florid type to a fibrous type. The Ki‐67 labeling index (LI) of gynecomastia specimen was investigated and higher Ki‐67 LI was observed in florid and intermediate than in fibrous gynecomastia ( P = 0.017). A correlation was found between the duration of disease and Ki‐67 LI ( P = 0.041): the shorter the duration the higher the Ki‐67 LI. Thus, Ki‐67 LI seems a useful tool to examine proliferation activity of gynecomastia and can assist in determination of appropriate treatment of gynecomastia with hormonal therapy.