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Distinct expression of Kaposi’s sarcoma‐associated herpesvirus‐encoded proteins in Kaposi’s sarcoma and multicentric Castleman’s disease
Author(s) -
Abe Yasuhisa,
Matsubara Daisuke,
Gatanaga Hiroyuki,
Oka Shinichi,
Kimura Satoshi,
Sasao Yuki,
Saitoh Kiyoshi,
Fujii Takeshi,
Sato Yuko,
Sata Tetsutaro,
Katano Harutaka
Publication year - 2006
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2006.02017.x
Subject(s) - lytic cycle , kaposi's sarcoma associated herpesvirus , sarcoma , castleman disease , pathology , immunohistochemistry , lesion , biology , virology , kaposi's sarcoma , medicine , virus , cancer research , herpesviridae , disease , human herpesvirus , viral disease
The expression of Kaposi’s sarcoma‐associated herpesvirus (KSHV/HHV‐8)‐encoded proteins is herein demonstrated in Kaposi’s sarcoma (KS) and multicentric Castleman’s disease (MCD) in a single lymph node derived from a patient with acquired immunodeficiency syndrome. Immunohistochemistry revealed that both lytic and latent KSHV proteins were expressed in cells of the MCD lesion. KSHV‐encoded viral interleukin‐6 was also detected in follicular dendritic cells of the germinal center. Cytoplasmic localization of open reading frame 59 protein and latency‐associated nuclear antigen suggested KSHV activation in the MCD lesion. Moreover, a high copy number of KSHV was detected in the blood. Clinically, pegylated‐liposomal doxorubicin induced regression of not only KS, but also lymphadenopathy of the MCD lesion with a decrease in KSHV load and human interleukin‐6 in the blood. To the best of the authors’ knowledge this is the first case demonstrating differential expression of virus proteins in two KSHV‐associated diseases, KS and MCD, in the same section. The case confirms lytic KSHV infection in MCD, and suggests that clinical symptoms of MCD might be closely linked with KSHV activation.