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Combined hepatocellular carcinoma and cholangiocarcinoma with components of mucinous carcinoma arising in a cirrhotic liver
Author(s) -
Morita Daisaku,
Kagata Yutaka,
Ogata Sho,
Tsuda Hitoshi,
Hatsuse Kazuo,
Mochizuki Hidetaka,
Matsubara Osamu
Publication year - 2006
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2006.01950.x
Subject(s) - hepatocellular carcinoma , intrahepatic cholangiocarcinoma , pathology , medicine , cirrhosis , immunohistochemistry , carcinoma , lymph node , lymph , ascites , gastroenterology
A rare autopsy case of combined hepatocellular and cholangiocarcinoma, occurring in a 54‐year‐old man with liver cirrhosis, is presented. Initial laboratory data included CEA 52.1 ng/mL, DUPAN‐2 1600 U/mL, AFP 2 ng/mL, and negativity for hepatitis B surface antigen, hepatitis B early antigen and hepatitis B core antibody. Ultrasonography and CT scan showed a large tumor node in the liver with ringed enhancement, swelling of several para‐aortic lymph nodes, and ascites. Clinically, it was not possible to determine whether the hepatic tumor was an intrahepatic cholangiocarcinoma or a metastatic carcinoma. Histologically, the primary lesion was composed solely of hepatocellular carcinoma (HCC) with a trabecular pattern, and the intrahepatic metastases consisted of a variable admixture of HCC and cholangiocarcinoma (CC) with excessive mucin production. Interestingly, the tumor cell cluster showing a trabecular growth pattern produced mucin and had immunohistochemical expression of hepatocyte, cytokeratins 7 and 8. It is concluded that these hepatic tumor cells had both HCC and CC characters.