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Pancreatic, hepatic, splenic, and mesenteric mucinous cystic neoplasms (MCN) are lumped together as extraovarian MCN
Author(s) -
Shiono Saori,
Suda Koichi,
Nobukawa Bunsei,
Arakawa Atsushi,
Yamasaki Shigetaka,
Sasahara Noriko,
Hosokawa Yoshinori,
Suzuki Fujihiko
Publication year - 2006
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2006.01926.x
Subject(s) - desmin , stroma , pancreas , pathology , vimentin , biology , mucin , endocrinology , medicine , immunohistochemistry
Mucinous cystic neoplasms (MCN) of the pancreas are mucin‐producing cystic tumors with an ovarian‐like stroma (OLS). In the present study MCN were obtained from 27 patients. These MCN were derived from 22 pancreas, three livers, spleen, and mesentery. MCN in various organs have common clinicopathological profiles, being unilocular or multilocular cystic tumors, with a fibrous capsule and lined by mucin‐secreting epithelium associated with an underlying subepithelial OLS. The OLS showed strong positivity for α‐smooth muscle actin (α‐SMA) and vimentin and weak, focal positivity for desmin. Both estrogen receptors and progesterone receptors were expressed in the nuclei of OLS cells. In addition, 20 ovarian MCN and 13 normal ovaries were studied with particular attention to the stroma. The stroma of ovarian MCN was strongly immunopositive for α‐SMA and vimentin and focally positive for desmin, whereas normal ovarian stroma was immunonegative for both α‐SMA and desmin. The OLS of MCN mentioned here was similar to the septa of ovarian MCN but not to ovarian stroma. In conclusion, MCN in various organs should be lumped together as ‘extraovarian’ MCN. The OLS was identified on the basis of myofibroblastic proliferation both in response to neoplastic development and dependent on hormones.