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Low‐grade fibromyxoid sarcoma arising in the big toe
Author(s) -
Kusumi Tomomi,
Nishikawa Shinji,
Tanaka Masanori,
Ogawa Taro,
Jin Hiromichi,
Sato Fuyuki,
Toh Satoshi,
Hasegawa Tadashi,
Kijima Hiroshi
Publication year - 2005
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2005.01910.x
Subject(s) - sarcoma , pathology , myxofibrosarcoma , stroma , differential diagnosis , medicine , fibroma , anatomy , immunohistochemistry
Low‐grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58‐year‐old man who underwent excision of the tumor. The tumor was well‐demarcated. Histologically, there were proliferating spindle‐shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette‐like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low‐grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS / CREB3L2 and FUS / CREB3L1 fusion genes from the formalin‐fixed and paraffin‐embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate.