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Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma
Author(s) -
Kase Satoru,
Saito Wataru,
Yoshida Kazuhiko,
Namba Kenichi,
Osaki Mitsuhiko,
Ohgami Kazuhiro,
Shiratori Kenji,
Kitaichi Nobuyoshi,
Adachi Hironobu,
Ito Hisao,
Ohno Shigeaki
Publication year - 2005
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2005.01870.x
Subject(s) - enucleation , pathology , thymidine phosphorylase , epithelioid cell , melanoma , medicine , ciliary body , choroid , immunohistochemistry , stroma , pathogenesis , retina , biology , cancer , cancer research , surgery , neuroscience
Reported herein is a case of 62‐year‐old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 × 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.