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Adenoid glioblastoma arising in a patient with neurofibromatosis type‐1
Author(s) -
Miyata Shiro,
Sugimoto Tetsuaki,
Kodama Takao,
Akiyama Yutaka,
Nakano Shinichi,
Wakisaka Shinichiro,
Itoh Hiroshi,
Kataoka Hiroaki
Publication year - 2005
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2005.01835.x
Subject(s) - adenoid , neurofibromatosis , pathology , medicine , glial fibrillary acidic protein , differential diagnosis , basophilic , glioblastoma , eosinophilic , adenoid cystic carcinoma , immunohistochemistry , cancer research , carcinoma
An unusual case of glioblastoma with adenoid structures arising in a 30‐year‐old Japanese woman with neurofibromatosis type‐1 (NF1) is reported. The patient was admitted to University of Miyazaki Hospital, complaining of headache, nausea and vomiting. From the neuroradiological findings the patient was diagnosed as having glioblastoma, and the tumor was surgically resected. Histologically, the tumor consisted mainly of dark basophilic cells showing prominent tubular or glandular structures surrounded by large eosinophilic cells, in addition to the typical glioblastoma features in the periphery of the tumor. Both cells showed strong stainability with glial fibrillary acidic protein (GFAP) and S‐100 protein immunohistochemically, so that the tumor was classified as adenoid glioblastoma. Several cases of glioblastoma have been reported to reveal the adenoid or epithelioid differentiation. The patients with NF1 are prone to develop malignant tumors including glioblastoma, but no cases representing adenoid glioblastoma associated with NF1 have been reported. This report is considered to be the first case of adenoid glioblastoma arising in a patient with NF1. The recognition of the existence of epithelial features of glioblastoma would be important in differential diagnosis of epithelioid tumors of the brain including metastatic carcinomas.