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Loss of expression of E‐cadherin and β‐catenin is associated with progression of pulmonary adenocarcinoma
Author(s) -
Awaya Hirokazu,
Takeshima Yukio,
Amatya Vishwa Jeet,
Ishida Hajime,
Yamasaki Masahiro,
Kohno Nobuoki,
Inai Kouki
Publication year - 2005
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2005.01784.x
Subject(s) - atypical adenomatous hyperplasia , adenocarcinoma , pathology , immunohistochemistry , cadherin , beta catenin , medicine , catenin , hyperplasia , lung , atypical hyperplasia , carcinoma , biology , cancer , cell , gene , wnt signaling pathway , genetics , biochemistry
The aim of the present study was to determine the association of loss of membranous expression of epithelial (E)‐cadherin and β‐catenin with the progression of pulmonary adenocarcinoma. The expression of E‐cadherin and β‐catenin was examined in 154 cases of pulmonary adenocarcinoma, including 49 cases of atypical adenomatous hyperplasia (AAH), 40 cases of bronchioloalveolar carcinoma (BAC), 42 cases of BAC‐dominant type of adenocarcinoma with mixed subtypes (early MX) and 23 cases of BAC‐recessive type of adenocarcinoma with mixed subtypes (overt MX), by immunohistochemistry. E‐cadherin expression was positive in all cases of AAH, in 37 cases (92.5%) of BAC and in 34 cases (81.0%) of early MX, while it was positive in three cases (13.0%) of overt MX. β‐Catenin expression was positive in 47 cases (95.9%) of AAH, in 28 cases (70%) of BAC, in 32 cases (76.2%) of early MX and in 11 cases (47.8%) of overt MX. The rates of expression of E‐cadherin and β‐catenin among cases of AAH, BAC, early MX and overt MX were significantly reduced. Loss of expression of E‐cadherin and β‐catenin may play an important role in the progression of pulmonary adenocarcinoma, and these events occur before structural destruction of the alveolar wall by invasion of carcinoma cell.