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Combined signet ring cell and glassy cell carcinoma of the uterine cervix arising in a young Japanese woman: A case report with immunohistochemical and histochemical analyses
Author(s) -
Moritani Suzuko,
Ichihara Shu,
Kushima Ryoji,
Sugiura Fumiyoshi,
Mushika Masafumi,
Silverberg Steven G.
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01756.x
Subject(s) - adenosquamous carcinoma , pathology , immunohistochemistry , carcinoma , cervix , signet ring cell , biology , signet ring cell carcinoma , cancer , adenocarcinoma , medicine
Signet ring cell carcinoma and glassy cell carcinoma are both rare histological subtypes of uterine cervical cancer. This report is of a case of uterine cervical carcinoma arising in a 29‐year‐old woman who had major components of signet ring cell carcinoma and glassy cell carcinoma within the same tumor. Histochemical and immunohistochemical analyses, including high and low molecular weight cytokeratins, p63 and MUC5AC, additionally demonstrated the squamous and adenocarcinomatous differentiation in the neoplastic cells, which showed otherwise unclassifiable morphology on the haematoxylin–eosin sections. A wide range of differentiation described above supports the speculation that glassy cell carcinoma may arise from the multipotential immature cells that can differentiate into both squamous and glandular cells. It would be precise to classify this tumor as adenosquamous carcinoma. Although adenosquamous carcinoma is not a rare histological subtype in the uterine cervix, it should be necessary to report the presence of glassy cells and signet ring cells when present because the presence of both components is associated with an unfavorable clinical behavior.