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Laminin 5 β3 and γ 2 chains are frequently coexpressed in cancer cells
Author(s) -
Akimoto Shingo,
Nakanishi Yukihiro,
Sakamoto Michiie,
Kanai Yae,
Hirohashi Setsuo
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01681.x
Subject(s) - laminin , colorectal cancer , pathology , immunohistochemistry , cancer , carcinoma , cell , biology , cancer research , stromal cell , cytoplasm , cancer cell , medicine , microbiology and biotechnology , biochemistry
Laminin 5 plays an important role in cell migration during tumor invasion and tissue remodeling. However, previous studies have not clarified whether laminin 5 β3 chain is coexpressed with laminin 5 γ 2 chain in cancer cells. The present immunohistochemical study investigated the distribution of the laminin 5 β3 and γ 2 chains in 20 cases of squamous cell carcinoma of the tongue and 17 cases of colorectal carcinoma. Laminin 5 β3 and γ 2 chains were expressed in the cytoplasm of tumor cells. Tumor cells at the cancer–stromal interface and at the invasive front frequently showed immunopositivity for laminin 5 β3 and γ 2 chains in both squamous cell carcinoma of the tongue and colorectal carcinoma. Furthermore, strong expressions of these two proteins were observed in cancer cells invading in a scattered manner. Laminin 5 β3 expression correlated significantly with laminin 5 γ 2 expression in 20 cases of squamous cell carcinoma of the tongue ( P = 0.0002) and 17 cases of colorectal carcinoma ( P < 0.0001). These results suggest that in squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 γ 2 chain and β3 chain are both important in the invasiveness of cancer cells.