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Dumbbell‐shaped leiomyosarcoma of the inferior vena cava with foci of rhabdoid changes and osteoclast‐type giant cells
Author(s) -
Nikaido Takashi,
Endo Yasuhiko,
Nimura Satoshi,
Ishikura Hiroshi,
Ushigome Shinichiro
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01616.x
Subject(s) - dumbbell , pathology , inferior vena cava , osteoclast , anatomy , medicine , leiomyosarcoma , radiology , receptor , physical therapy
An inferior vena cava (IVC) tumor was incidentally found in a 67‐year‐old Japanese man. The resected tumor was lobulated and multinodular, measuring 14.0 × 6.5 × 7.0 cm, showing a dumbbell‐shaped appearance with a central constriction. The tumor showed both intra‐ and extra‐luminal growth. The tumor was primarily composed of well‐differentiated leiomyosarcoma. Spindle tumor cells in the well‐differentiated area were positive for vimentin, muscle actin, α‐smooth muscle actin, and desmin. Foci of rhabdoid cells and osteoclast‐type multinucleated giant cells were also found. Rhabdoid cells ultrastructurally had paranuclear aggregates or whorls of intermediate filaments that were positive for vimentin, low molecular weight cytokeratin, and desmin. Osteoclast‐type multinucleated giant cells were positive for only CD68 antigen, suggesting a reactive histiocytic lineage. To the best of our knowledge, this is the first case of IVC leiomyosarcoma accompanied by both rhabdoid tumor cells and osteoclast‐type reactive multinucleated giant cells. These unusual features should be kept in mind in the diagnosis of dumbbell‐shaped retroperitoneal tumors that involve the IVC.