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Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix
Author(s) -
Murata Shinichi,
Miyata Kazuyuki,
Takaishi Koji,
Mochizuki Kunio,
Nakazawa Tadao,
Kondo Tetsuo,
Nakamura Nobuki,
Katoh Ryohei
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01584.x
Subject(s) - pathology , cytokeratin , adenocarcinoma , immunohistochemistry , cervix , papillary adenocarcinoma , carcinoma , papillary tumor , columnar cell , medicine , transitional cell carcinoma , epithelium , cancer , bladder cancer
A mixed papillary adenocarcinoma and transitional cell carcinoma (MAcTcc) was discovered in the uterine cervix of a 38‐year‐old woman. A condylomatous papillary lesion was found in the uterine cervix during a colposcopic study and histopathological examination showed that the tumor was composed of two different neoplastic subtypes. One was an adenocarcinoma (AC) component showing papillary and tubular structure with endocervical and intestinal differentiation; the other was a transitional cell carcinoma (TCC) component showing papillary excrescence mimicking papillary TCC of urothelial origin. To characterize the tumor, an immunohistochemical study of cytokeratins (CK) was performed. The AC component showed immunoreactivities similar to conventional adenocarcinomas: positive immunoreactivity of low‐molecular‐weight cytokeratins 7, 8 and 19, and negative immunoreactivity of CK20 and high‐molecular‐weight cytokeratin (34βE12). The lower epithelial layer of the TCC component showed different immunoreactivity, but the superficial epithelial layer had similar immunohistochemical findings to the AC component. These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix.