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Deposition of IgD, alpha‐1‐antitrypsin and alpha‐1‐antichymotrypsin on Demodex folliculorum and D. brevis infesting the pilosebaceous unit
Author(s) -
Tsutsumi Yutaka
Publication year - 2004
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.2004.01581.x
Subject(s) - immunoglobulin d , immunoglobulin e , alpha (finance) , immunology , albumin , biology , pathology , microbiology and biotechnology , chemistry , antibody , medicine , endocrinology , construct validity , nursing , b cell , patient satisfaction
A total of seven routinely processed biopsy specimens of facial skin lesions with infestation of Demodex folliculorum or D. brevis were immunostained for plasma proteins and secretory proteins. The cuticular layer of the mites located within the pilosebaceous unit was selectively immunoreactive for IgD (delta chain), alpha‐1‐antitrypsin and alpha‐1‐antichymotrypsin. Negative results were obtained for IgG, IgA, IgM, IgE, albumin, fibrinogen, C3, amyloid P component, prealbumin, lysozyme and lactoferrin. These findings suggest a novel function of IgD and serum protease inhibitors as a protective host response to the mite.